Blar i forfatter "Kral, Rita"
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Cortical bone and fracture risk: The Tromsø Study
Kral, Rita (Doctoral thesis; Doktorgradsavhandling, 2018-03-20)Background: The aim of this thesis was to explore the association of the cortical architecture of the proximal femoral shaft with non-vertebral fractures. We tested the hypotheses that: (i) cortical parameters are associated with fracture risk independent of Fracture Risk Assessment Tool (FRAX) or Garvan estimates, (ii) women with fractures that are unidentified by FRAX but identified by cortical ... -
Increased cortical porosity and reduced cortical thickness of the proximal femur are associated with nonvertebral fracture independent of Fracture Risk Assessment Tool and Garvan estimates in postmenopausal women
Kral, Rita; Osima, Marit; Borgen, Tove Tveitan; Vestgaard, Roald; Richardsen, Elin; Bjørnerem, Åshild (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-09-25)The Fracture Risk Assessment Tool (FRAX) and Garvan Calculator have improved the individual prediction of fracture risk. However, additional bone measurements that might enhance the predictive ability of these tools are the subject of research. There is increasing interest in cortical parameters, especially cortical porosity. Neither FRAX nor Garvan include measurements of cortical architecture, ... -
Women with fracture, unidentified by FRAX, but identified by cortical porosity, have a set of characteristics that contribute to their increased fracture risk beyond high FRAX score and high cortical porosity
Kral, Rita; Osima, Marit; Vestgaard, Roald; Richardsen, Elin; Bjørnerem, Åshild (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-08-25)The Fracture Risk Assessment Tool (FRAX) is widely used to identify individuals at increased risk for fracture. However, cortical porosity is associated with risk for fracture independent of FRAX and is reported to improve the net reclassification of fracture cases. We wanted to test the hypothesis that women with fracture who are unidentified by high FRAX score, but identified by high cortical ... -
Women with type 2 diabetes mellitus have lower cortical porosity of the proximal femoral shaft using low-resolution CT than nondiabetic women, and increasing glucose is associated with reduced cortical porosity
Osima, Marit; Kral, Rita; Borgen, Tove Tveitan; Høgestøl, Ingvild Kristine; Joakimsen, Ragnar Martin; Eriksen, Erik Fink; Bjørnerem, Åshild (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-01)<p>Increased cortical porosity has been suggested as a possible factor increasing fracture propensity in patients with type 2 diabetes mellitus (T2DM). This is a paradox because cortical porosity is generally associated with high bone turnover, while bone turnover is reduced in patients with T2DM. We therefore wanted to test the hypothesis that women with T2DM have lower bone turnover markers (BTM) ...